Rivarospir 15 mg 42 tablets

Tradename

Rivarospir

Rivarospire

Compound:

Each tablet contains:

rivaroxaban micronized 15 mg

Auxiliary components:

Lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate.

Properties

Rivaroxaban is a highly selective direct factor Xa inhibitor with high oral bioavailability.

Activation of factor X to form factor Xa via the intrinsic and extrinsic coagulation pathways plays a central role in the coagulation cascade. Factor Xa is a component of the emerging prothrombinase complex, the action of which leads to the conversion of prothrombin to thrombin. As a result, these reactions lead to the formation of a fibrin thrombus and activation of platelets by thrombin. One molecule of factor Xa catalyzes the formation of more than 1000 thrombin molecules, which is called the «thrombin explosion». The reaction rate of factor Xa bound in prothrombinase is increased by 300,000 times compared to that of free factor Xa, which provides a sharp jump in the level of thrombin. Selective factor Xa inhibitors can stop the «thrombin burst». Thus, rivaroxaban affects the results of some specific or general laboratory tests used to evaluate clotting systems.

Indications

— prevention of stroke and systemic thromboembolism in patients with non-valvular atrial fibrillation;

-treatment of deep vein thrombosis and pulmonary embolism and prevention of recurrence of DVT and PE.

Dosage and administration

For oral administration.

Rivarospir 15 mg and 20 mg should be taken with food.

The dose and course of treatment is prescribed by the doctor after the examination.

Contraindications

Hypersensitivity to the active ingredient or to any of the excipients that make up the drug.

— Active clinically significant bleeding.

— Pathological change or condition, if it is considered as a significant risk of massive bleeding. These include:

Side effects

From the blood and lymphatic system:

Anemia (including related

laboratory parameters).

Storage

Store at a temperature not exceeding 30 degrees.

Package:

The cardboard box contains 3 blisters of 14 tablets, paper instructions.