Spectone 100 mg 20 tablets

Tradename

Specton

Spectone

Compound:

Each tablet contains:

Spironolactone 100 mg

Properties

Potassium-, magnesium-sparing diuretic. It is a competitive aldosterone antagonist in terms of its effect on the distal nephron (competes for binding sites on cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent region of the collecting ducts and distal tubules), increases the excretion of Na +, Cl- and water and reduces the excretion of K + and urea, reduces the titratable acidity of urine. Increased diuresis causes a hypotensive effect, which is unstable. The hypotensive effect does not depend on the level of renin in the blood plasma and does not appear in normal blood pressure.

The diuretic effect is manifested on the 2nd-5th day of treatment.

Indications

Edema in chronic heart failure, cirrhosis of the liver (especially with the simultaneous presence of hypokalemia and hyperaldosteronism), with nephrotic syndrome.

Edema in the II and III trimesters of pregnancy.

Arterial hypertension, incl. with aldosterone-producing adrenal adenoma (as part of combination therapy).

Dosage and administration

Set individually depending on the severity of violations of water-electrolyte metabolism and hormonal status.

Adults:

With edematous syndrome — 100-200 mg / day (less often — 400 mg / day) in 2-3 doses daily for 14-21 days. Dose adjustment should be carried out taking into account the values of the concentration of potassium in the plasma. If necessary, courses are repeated every 10-14 days.

Contraindications

Addison’s disease, hyperkalemia, hypercalcemia, hyponatremia, chronic renal failure, anuria, liver failure, diabetes mellitus with confirmed or suspected chronic renal failure, diabetic nephropathy, first trimester of pregnancy, metabolic acidosis, menstrual irregularities or breast enlargement, hypersensitivity to spironolactone .

Precautionary measures:

Use with caution in AV blockade (the possibility of increased due to the development of hyperkalemia), decompensated liver cirrhosis, surgical interventions, taking drugs that cause gynecomastia, when taking local and general anesthetics, in elderly patients.

Side effects

From the digestive system: nausea, vomiting, abdominal pain, gastritis, ulceration and bleeding in the gastrointestinal tract, intestinal colic, diarrhea or constipation.

From the side of the central nervous system: dizziness, drowsiness, lethargy, headache, lethargy, ataxia.

From the side of metabolism: an increase in the concentration of urea, hypercreatininemia, hyperuricemia, impaired water-salt metabolism and acid-base balance (metabolic hypochloremic acidosis or alkalosis).