Xanthistop 80 mg 30 tablets
Tradename
Xanthistop (Xanthistop)
Compound:
Each tablet contains:
Febuxostat 80 mg
Properties
Selective non-purine xanthine oxidase inhibitor, 2-aryl triazole derivative.
The enzyme xanthine oxidase catalyzes two steps of purine metabolism: the oxidation of hypoxanthine to xanthine and then the oxidation of xanthine to uric acid.
As a result of selective inhibition of xanthine oxidase (oxidized and reduced forms) by febuxostat, a decrease in the concentration of uric acid in the blood serum occurs. The in vitro inhibition constant is less than 1 nM.
Indications
Treatment of chronic hyperuricemia in conditions accompanied by the deposition of urate crystals (in the presence of tophi and / or gouty arthritis, including a history).
Treatment and prevention of hyperuricemia in adult patients during cytostatic therapy of hemoblastoses with a moderate to high risk of developing tumor disintegration syndrome (only for a dose of 120 mg).
Dosage and administration
Taken inside.
The dose is 80-120 mg 1 time / day. The duration of treatment is set individually, depending on the indications.
The goal of treatment is to lower and maintain serum uric acid levels below 6 mg/dL (357 µmol/L).
Contraindications
Pregnancy, breastfeeding period; children’s age up to 18 years; hypersensitivity to febuxostat.
Precautionary measures:
Febuxostat should only be started after an acute attack of gout has resolved. The use of febuxostat can provoke the development of an acute attack of gout due to the release of urate from tissue depots and a subsequent increase in the concentration of uric acid in the blood serum. For the prevention of gout attacks, the simultaneous use of NSAIDs or colchicine for at least 6 months is recommended.
Side effects
From the nervous system: often — headache; infrequently — dizziness, paresthesia, hemiparesis, drowsiness, change in taste perception, hypesthesia, hyposmia (weakening of smell).
From the endocrine system: infrequently — an increase in the concentration of TSH in the blood plasma.
From the side of metabolism: often — attacks of gout; infrequently — diabetes mellitus, hyperlipidemia.