Oseltamivir, 10 capsules
Trade Name:
Oseltamivir
Composition
Each capsule contains:
Oseltamivir phosphate 75 mg
Properties
Antiviral agent. It is a prodrug whose active metabolite (oseltamivir carboxylate) selectively inhibits influenza virus types A and B neuraminidase. Neuraminidase is a glycoprotein that catalyzes the cleavage of the bond between the terminal sialic acid and sugar, thereby contributing to the spread of the virus in the respiratory tract (the release of virions from the infected cell and penetration into the epithelial cells of the respiratory tract, preventing the inactivation of the virus by epithelial mucus). Oseltamivir carboxylate acts outside cells and competitively inhibits viral neuraminidase. It inhibits the growth of the influenza virus in vitro and suppresses the replication of the virus and its pathogenicity in vivo. Reduces the release of influenza A and B viruses from the body.
Does not affect the production of antibodies in response to the introduction of an inactivated influenza vaccine.
The frequency of resistance of clinical isolates of the virus is 2%.
Indications
Influenza types A and B.
Dosage and administration
Taken orally, regardless of food intake.
When treating, the intake should be started no later than 2 days from the moment the symptoms of the disease develop at a dose of 75 mg 2 times / day for 5 days. Increasing the dose of more than 150 mg / day does not lead to an increase in the effect.
For the prevention of influenza types A and B in adults — 75 mg 1-2 times / day for 6 weeks. (during the influenza epidemic). The maximum daily dose for adults is 150 mg.
Side effects
From the digestive system: nausea, vomiting (usually when taken in high doses, or in the first days of treatment); rarely — diarrhea, abdominal pain.
From the side of the central nervous system: insomnia, dizziness, headache.
From the respiratory system: nasal congestion, sore throat, cough.
Storage
Store at a temperature not exceeding 30°C.
Package:
Carton box contains 10 capsules, paper leaflet.