Stomigas 20 mg

Trade name:

Stomigas

Ingredients:

Properties

Inhibits the activity of H + / K + — adenosine triphosphate (ATP-phase (H + / K + -adenosine triphosphate (ATP) -phase, it is also a «proton pump» or «proton pump») in the parietal cells of the stomach, thereby blocking the transfer of ions hydrogen and the final stage of the synthesis of hydrochloric acid in the stomach.Omeprazole is a prodrug.In the acidic environment of the tubules of parietal cells, omeprazole is converted to the active metabolite sulfenamide, which inhibits the membrane H + / K + — adenosine triphosphate (ATP) -phase, connecting to it due to the disulfide bridge This explains the high selectivity of the action of omeprazole specifically on parietal cells, where there is an environment for the formation of sulfenamide.Biotransformation of omeprazole into sulfenamide occurs quickly (after 2-4 minutes).Sulfenamide is a cation and is not absorbed. acid at the final stage.Reduces the total volume of gastric secretion and inhibits the release of pepsin. azole showed gastroprotective activity, the mechanism of which is not clear. It does not affect the production of the intrinsic factor of Castle and the rate of transition of the food mass from the stomach to the duodenum. Omeprazole does not act on acetylcholine and histamine receptors.Sodium bicarbonate is an antacid agent that regulates the acid-base balance. It has alkaline properties, increases the alkaline reserve of the blood. When taken orally, it quickly neutralizes the hydrochloric acid of gastric juice and has a quick, but short-term antacid effect.

Indications

Short-term treatment of an active duodenal ulcer. Benign gastric ulcer. Gastroesophageal reflux disease. Erosive esophagitis. Maintaining the healing of erosive esophagitis. Reducing the risk of upper gastrointestinal bleeding in critically ill grade III patients

Dosage and administration

Since both 20 mg and 40 mg capsules contain the same amount of sodium bicarbonate (1100 mg), two 20 mg capsules are not equivalent to one Stomigas capsule 40 mg, so two capsules of 20 mg Stomigas should not be replaced by one capsule of Stomigas 40 mg. The drug should be taken on an empty stomach one hour before meals. The doctor selects the dosage individually. On average, 20-40 mg of omeprazole are taken for 4-8 weeks .

Contraindications

The drug is contraindicated in patients with known hypersensitivity to any component of the drug. Hypersensitivity reactions may include anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute interstitial nephritis, and urticaria.

Warnings and precautions:

Symptomatic response to omeprazole therapy does not exclude the presence of malignant neoplasms of the stomach. Atrophic gastritis has sometimes been noted during biopsy of the stomach body in patients receiving omeprazole for a long time.

Side effects

Digestive organs: diarrhea or constipation, abdominal pain, nausea, vomiting, flatulence. pain, dizziness, agitation, depression, in patients with previous severe liver disease — encephalopathy.

On the part of the musculoskeletal system: in some cases — arthralgia, myasthenia gravis, myalgia.

On the part of the hematopoietic system: in some cases — leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.

Storage

Store at a temperature not exceeding 30°C.

Package:

Carton box contains 2 blisters of 10 capsules.