Stomigas 40/1,100 mg

Trade Name:

Stomigas

Composition

Each capsule contains:

Omeprazole 40 mg

Sodium bicarbonate 1,100 mg

Other ingredients:

Croscarmellose sodium, sodium stearyl fumarate, titanium dioxide, gelatin.

Properties

Omeprazole is an antiulcer drug, an inhibitor of the enzyme H + / K + -adenosine triphosphate (ATP) -phase. Inhibits the activity of H + / K + — adenosine triphosphate (ATP-phase (H + / K + -adenosine triphosphate (ATP) -phase, it is also a «proton pump» or «proton pump») in the parietal cells of the stomach, thereby blocking the transfer of ions hydrogen and the final stage of the synthesis of hydrochloric acid in the stomach.Omeprazole is a prodrug.In the acidic environment of the tubules of parietal cells, omeprazole is converted to the active metabolite sulfenamide, which inhibits the membrane H + / K + — adenosine triphosphate (ATP) -phase, connecting to it due to the disulfide bridge This explains the high selectivity of the action of omeprazole specifically on parietal cells, where there is a medium for the formation of sulfenamide.Biotransformation of omeprazole into sulfenamide occurs quickly (after 2-4 minutes).Sulfenamide is a cation and is not absorbed.

Omeprazole suppresses basal and stimulated by any stimulus secretion of hydrochloric acid at the final stage. Reduces the total volume of gastric secretion and inhibits the release of pepsin. Omeprazole has a gastroprotective activity, the mechanism of which is not clear. It does not affect the production of the intrinsic factor of Castle and the rate of transition of the food mass from the stomach to the duodenum. Omeprazole does not act on acetylcholine and histamine receptors.Sodium bicarbonate is an antacid that regulates the acid-base balance. It has alkaline properties, increases the alkaline reserve of the blood. When taken orally, it quickly neutralizes the hydrochloric acid of gastric juice and has a quick, but short-term antacid effect.

Indications

Short-term treatment of active duodenal ulcer.

Benign stomach ulcer.

Gastroesophageal reflux disease.

Dosage and administration

Because both 20 mg and 40 mg capsules contain the same amount of sodium bicarbonate (1100 mg), two 20 mg capsules are not equivalent to one Stomigas 40 mg capsule, so two Stomigas 20 mg capsules should not be substituted for one Stomigas 40 mg capsule.

The drug should be taken on an empty stomach one hour before meals.

The dosage is selected by the doctor individually.

Contraindications

The drug is contraindicated in patients with known hypersensitivity to any component of the drug. Hypersensitivity reactions may include anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute interstitial nephritis, and urticaria.

Warnings and precautions:

Symptomatic response to omeprazole therapy does not exclude the presence of malignant neoplasms of the stomach.

Side effects

From the digestive system: diarrhea or constipation, abdominal pain, nausea, vomiting, flatulence.

From the nervous system: in patients with severe concomitant somatic diseases — headache, dizziness, agitation, depression, in patients with previous severe liver disease — encephalopathy.

From the musculoskeletal system: in some cases — arthralgia, myasthenia gravis, myalgia.

Storage

Store at a temperature not exceeding 30°C.

Package:

Carton box contains 2 blisters of 10 capsules.