Exforge 5/160/12,5

Trade Name:

Exforge 5/160/12,5

Composition

Each tablet contains:

5 mg amlodipine, 160 mg valsartan, 12,5 mg hydrochlorothiazide

Inactive ingredients:

Microcrystalline cellulose, crospovidone, silica, colloidal anhydrous, magnesium stearate, hypromellose, macrogol 4000, talc, titanium dioxide, iron oxide, yellow (E172) red (E172)

Properties

A combined antihypertensive drug containing three components with a complementary mechanism for controlling blood pressure: amlodipine (calcium channel blocker), valsartan (angiotensin II receptor antagonist) and hydrochlorothiazide (thiazide diuretic). The combination of these components leads to a more pronounced decrease in blood pressure compared to that against the background of monotherapy with each drug separately.

Amlodipine is a dihydropyridine derivative, a calcium channel blocker. It has an antianginal and hypotensive effect. Inhibits the transmembrane transition of calcium ions into cardiomyocytes and smooth muscle cells of the vascular wall.

Valsartan does not interact with and does not block the receptors of other hormones or ion channels involved in the regulation of the functions of the cardiovascular system.

Indications

Arterial hypertension II and III degree.

Dosage and administration

The drug is taken orally, regardless of food intake, preferably in the morning with a small amount of water.

The recommended daily doses of the drug are:

5 mg + 160 mg + 12.5 mg (1 tablet containing amlodipine + valsartan + hydrochlorothiazide in doses of 5 mg + 160 mg + 12.5 mg);

Contraindications

-expressed violations of liver function;

-biliary cirrhosis and cholestasis;

-severe renal dysfunction, anuria, patients on hemodialysis;

Side effects

The most common adverse events observed in clinical studies (regardless of the identification of a connection with the use of the drug) were dizziness, peripheral edema, headache, dyspepsia, fatigue, muscle spasm, back pain, nasopharyngitis, nausea.

Storage

Store in a cool dry place at a temperature not exceeding 30°C

Package:

Carton box contains 14 film coated tablets,paper leaflet