Cardiomep 200 mg

Trade Name:

Cardiomep 200 mg

Composition

Each tablet contains:

Amiodarone hydrochloride 200 mg

Inactive ingredients:

Microcrystalline cellulose, corn starch, lactose monohydrate, magnesium stearate

Properties

Class III antiarrhythmic drug with antianginal activity.

The antiarrhythmic effect is associated with the ability to increase the duration of the action potential of cardiomyocytes and the effective refractory period of the atria, ventricles, AV node, His bundle, Purkinje fibers. This is accompanied by a decrease in the automatism of the sinus node, a slowdown in AV conduction, and a decrease in the excitability of cardiomyocytes. It is believed that the mechanism for increasing the duration of the action potential is associated with the blockade of potassium channels (the excretion of potassium ions from cardiomyocytes decreases). By blocking inactivated «fast» sodium channels, it has effects characteristic of class I antiarrhythmic drugs. It inhibits the slow (diastolic) depolarization of the membrane of the cells of the sinus node, causing bradycardia, inhibits AV conduction (the effect of class IV antiarrhythmics).

The antianginal effect is due to coronary dilating and antiadrenergic action, a decrease in myocardial oxygen demand. It has an inhibitory effect on α- and β-adrenergic receptors of the cardiovascular system (without their complete blockade). Reduces sensitivity to hyperstimulation of the sympathetic nervous system, the tone of the coronary vessels; increases coronary blood flow; slows heart rate; increases the energy reserves of the myocardium (by increasing the content of creatine sulfate, adenosine and glycogen).

Indications

Treatment and prevention of paroxysmal arrhythmias: life-threatening ventricular arrhythmias (including ventricular tachycardia), prevention of ventricular fibrillation (including after cardioversion), supraventricular arrhythmias (as a rule, with the ineffectiveness or impossibility of other therapy, especially those associated with WPW syndrome), incl. paroxysm of atrial fibrillation and flutter; atrial and ventricular extrasystole; arrhythmias against the background of coronary insufficiency or chronic heart failure, parasystole, ventricular arrhythmias in patients with Chagas myocarditis; angina.

Mode of application:

When taken orally for adults, the initial single dose is 200 mg. For children, the dose is 2.5-10 mg / day. The scheme and duration of treatment are set individually.

Side effects

Cardiovascular system: sinus bradycardia (refractory to m-anticholinergics), AV blockade, with prolonged use — progression of CHF, ventricular arrhythmia of the «pirouette» type, increased existing arrhythmia or its occurrence, with parenteral use — lowering blood pressure.

Endocrine system: the development of hypo- or hyperthyroidism.

Respiratory system: with prolonged use — cough, shortness of breath, interstitial pneumonia or alveolitis, pulmonary fibrosis, pleurisy, with parenteral use — bronchospasm, apnea (in patients with severe respiratory failure).

Contraindications

Sinus bradycardia, SSSU, sinoatrial blockade, AV block II-III degree (without the use of a pacemaker), cardiogenic shock, hypokalemia, collapse, arterial hypotension, hypothyroidism, thyrotoxicosis, interstitial lung disease, MAO inhibitors, pregnancy, lactation, increased sensitivity to amiodarone and iodine.

Contraindicated in pregnancy and lactation.

Amiodarone and desmethylamiodarone cross the placental barrier, their concentrations in the blood of the fetus, respectively, are 10% and 25% of the concentration in the mother’s blood.

Storage

Store at a temperature not exceeding 30°C.

Package:

Carton box contains 3 blisters of 10 tablets and paper leaflet.