Augram 400/57mg

Trade Name:

Augram 400/57mg

Broad spectrum antibiotic

Composition

Each 5 ml contains:

Amoxicillin trihydrate 458.1mg equivalent to 400 mg Amoxicillin base + Potassium clavulanate 67.8 equivalent to 57mg clavulanic acid

Inactive Ingredients:

Microcrystalline cellulose (Avicel PH 101), sucrose, colloidal anhydrous silica (Aerosil200), syloid

Properties

Amoxicillin is a semi-synthetic broad-spectrum antibiotic with activity against many gram-positive and gram-negative microorganisms. At the same time, amoxicillin is susceptible to destruction by β-lactamases, and therefore the spectrum of activity of amoxicillin does not extend to microorganisms that produce this enzyme.

Clavulanic acid, a β-lactamase inhibitor structurally related to penicillins, has the ability to inactivate a wide range of β-lactamases found in microorganisms resistant to penicillins and cephalosporins. Clavulanic acid is reasonably effective against plasmid β-lactamases, which most often confer bacterial resistance, and less effective against chromosomal type 1 β-lactamases, which are not inhibited by clavulanic acid.

The presence of clavulanic acid in Augram protects amoxicillin from destruction by enzymes — β-lactamases, which allows expanding the antibacterial spectrum of amoxicillin.

Indications

Bacterial infections caused by microorganisms sensitive to the drug:

infections of the upper respiratory tract and ENT organs (for example, recurrent tonsillitis, sinusitis, otitis media), usually caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes;

infections of the lower respiratory tract: exacerbations of chronic bronchitis, lobar pneumonia and bronchopneumonia, usually caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis;

Dosage and administration

The drug is taken orally.

The dosage regimen is set individually depending on the age, body weight, kidney function of the patient, as well as the severity of the infection.

For optimal absorption and to reduce possible side effects on the digestive system, Augram is recommended to be taken at the beginning of a meal.

Contraindications

— hypersensitivity to amoxicillin, clavulanic acid, other components of the drug, beta-lactam antibiotics (for example, penicillins, cephalosporins) in history;

— previous episodes of jaundice or abnormal liver function when using a combination of amoxicillin with clavulanic acid in history;

— children’s age up to 3 months (for powder for suspension for oral administration 200 mg / 28.5 mg in 5 ml and 400 mg / 57 mg in 5 ml);

Side effects

Infectious and parasitic diseases: often — candidiasis of the skin and mucous membranes;

From the hematopoietic system: rarely — reversible leukopenia (including neutropenia) and reversible thrombocytopenia; very rarely — reversible agranulocytosis and reversible hemolytic anemia, prolongation of prothrombin time and bleeding time, anemia, eosinophilia, thrombocytosis.

On the part of the immune system: very rarely — angioedema, anaphylactic reactions, a syndrome similar to serum sickness, allergic vasculitis.

Storage

Store at a temperature not exceeding 25°C. Once opened, store in the refrigerator for up to 7 days.

Package:

The carton box contains 60 ml plastic bottle and suspension powder, paper instructions