Elidel 1% cream 15 g

Tradename

Elidel

Elidel

Structure:

Each gram of cream contains:

10 mg pimecrolimus

Auxiliary components:

sodium hydroxide, citric acid anhydrous, benzyl alcohol, sodium cetostearyl sulfate, mono- and diglycerides, cetyl alcohol, stearyl alcohol, propylene glycol, Oleyl alcohol, medium-chain triglycerides, purified water

Properties

Pimecrolimus — a derivative of the macrolactam ascomycin, has an anti-inflammatory effect. Selectively inhibits the production and release of cytokines and mediators from Tlymphocytes and mast cells.

Pimecrolimus specifically binds to the cytosolic receptor macrophilin-12 and inhibits calciumdependent phosphatase — calcineurin.

Calcineurin inhibition leads to suppression of the proliferation of T-lymphocytes and prevents the transcription and production of early cytokines in T-helpers 1 and 2, such as interleukin-2, interferon gamma, interleukin interleukin-5, interleukin-10, tumor necrosi factor a and granulocyte-macrophage colonystimulating factor. Pimecrolimus and

Indications

Atopic dermatitis (eczema).

The drug is indicated for short-term and longterm use in adults, adolescents and children (over 2 years old).

Method of administration and dosage:

Contraindications

children under 2 years of age (since the

safety and efficacy of using Elidel cream in children under 2 years of age has not been studied);

-Application of Elidel cream to skin areas affected by an acute viral, bacterial or fungal infection;

Side effects

Often: local reactions (irritation, itching and redness of the skin), skin infections (folliculitis).

Sometimes: suppuration, worsening of the disease, herpes simplex, dermatitis caused the herpes simplex virus (herpetic eczema), molluscum contagiosum; local reactions such

as rash, pain, paresthesias, peeling, dryness, swelling, cutaneous papillomas, boils.