Septrin suspension 120 ml

Tradename

Septrine

Septrin

Composition

Each 5 ml of suspension contains:

Sulfamethoxazole 200 mg

Trimethoprim 40 mg

Auxiliary components:

macrogol glyceryl hydroxystearate, magnesium aluminosilicate, sodium carmellose, citric acid monohydrate, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium saccharinate, sodium hydrogen phosphate dodecahydrate, maltitol liquid, vanilla flavor, propylene glycol, purified water.

Properties

Combined antibacterial drug containing sulfamethoxazole and trimethoprim.

Sulfamethoxazole, similar in structure to PABA, disrupts the synthesis of dihydrofolic acid in bacterial cells, preventing the incorporation of PABA into its molecule.

Trimethoprim enhances the effect of sulfamethoxazole, disrupting the reduction of dihydrofolic acid to tetrahydrofolic acid, the active form of folic acid, which is responsible for protein metabolism and microbial cell division.

Indications

Treatment of infectious and inflammatory

diseases caused by microorganisms sensitive to the drug:

respiratory tract infections (including bronchitis, pneumonia, lung abscess, pleural empyema);

Contraindications

an established diagnosis of damage to the

liver parenchyma;

severe renal dysfunction in the absence of the ability to control the concentration of the drug in the blood plasma;

Side effects

The drug is generally well tolerated.

From the nervous system: headache, dizziness; in some cases — aseptic meningitis, depression, apathy, tremor, peripheral neuritis.

From the respiratory system: bronchospasm, dyspnea, cough, pulmonary infiltrates.