Gastrobiotic 550 mg 30 tablets

Tradename

Gastrobiotic

Gastrobiotic

Composition

Each tablet contains:

Rifaximin 550 mg

Auxiliary components:

sodium carboxymethyl starch, glyceryl palmitostearate, colloidal silicon dioxide, talc, microcrystalline cellulose.

Properties

Rifaximin is a broad-spectrum antibiotic from the rifamycin group. Like other members of this group, it irreversibly binds the beta subunits of the bacterial enzyme DNA-dependent RNA polymerase and, therefore, inhibits the synthesis of RNA and bacterial proteins. As result of irreversible binding to the enzyme, rifaximinexhibits bactericidal properties against susceptible bacteria. The drug has a

wide spectrum of antimicrobial activity, including most gram-negative and grampositive, aerobic and anaerobic bacteria. The broad antibacterial spectrum of rifaximin helps to reduce the pathogenic intestinal bacterial load, which causes some pathological conditions.

The drug reduces:

Indications

Treatment of gastrointestinal tract infections caused by bacteria sensitive to rifaximin, including: — acute gastrointestinal infections; travelers’diarrhea; — syndrome of overgrowth of microorganisms in the intestine; — with hepatic encephalopathy; — with symptomatic uncomplicated diverticular disease of the colon; — in chronic intestinal inflammation. Prevention of infectious complications in colorectal surgical interventions.

Method of administration and dosage:

The drug is taken orally with a glass of water, regardless of the meal. When treating diarrhea, adults and children over 12 years of age ar prescribed 200 mg (1 tablet) every 6 hours. Treatment of traveler’sdiarrhea should not exceed 3 days. The duration of treatment with Gastrobiotic@ should not exceed 7 days. A repeated course of treatment should be carried out no earlier than 20-40 days later. The total duration of treatment is determined by the clinical condition of the patients. Doses and frequency of administration can be changed on the recommendation of a doctor

Contraindications

— diarrhea, accompanied by fever and loose stools with blood; — intestinal obstruction

(including partial); — severe ulcerative intestinal lesion; — children under 12 years of age (efficacy and safety have not been established); — hereditary fructose intolerance, malabsorption glucose-galactose, sucraseisomaltase deficiency (for a dosage form of a granule for preparing a suspension for oral administration); — hypersensitivity to rifaximin or other rifamycins or to any of the components that make up the drug. With caution: renal failure, concomitant use with oral contraceptives, concomitant use with a Pglycoprotein inhibitor such as cyclosporin.

Precautions:

Side effects

From the side of the central nervous system: often — dizziness, headache; infrequently hypesthesia, migraine, paresthesia, drowsiness, pain in the sinuses; unknown light-headedness, agitation.On the part of the organ of vision: infrequently — diplopia. On the part of the inner ear: infrequently — pain in t ear, systemic dizziness; on the part of the respiratory system: infrequently — shortness of

breath, dry throat, nasal congestion, pain in the oropharynx, cough, rhinorrhea; on the part of the digestive system: often — bloating, pain in stomach, constipation, diarrhea, flatulence, nausea, tenesmus, vomiting, urge to defecate; infrequently — pain in the upper abdomen, ascites, dyspepsia, impaired gastrointestinal motility, secretion of mucus and blood with stools, dry lips, «hard» stool, increased AST activity, ageusia; unknown — change in liver function tests, heartburn. From the urinary system: infrequently — glucosuria, polyuria, pollakiuria, hematuria, proteinuria. From the skin and subcutaneous fat: infrequently — rash, sunburn; unknown — angioedema, allergic dermatitis, exfoliative dermatitis, eczema, erythema, pruritus, purpura, urticaria, erythematous rash, erythema of the palms, itching of the genitals.On the part of the musculoskeletal system: infrequently — back pain, spasm, muscles, muscle myalgia, neck pain. Infections: infrequently — candidiasis, herpes simplex, nasopharyngitis, pharyngitis, upper respiratory tract infections; unknown Clostridial infection. Reproductive system:

infrequently — polymenorrhea. Other: often fever. infrequently — rash, sunburn; unknown angioedema, allergic dermatitis, exfoliative dermatitis, eczema, erythema, pruritus, purpura, urticaria, erythematous rash, erythema of the palms, itching of the genitals.On the part of the musculoskeletal system: infrequently — back pain, spasm, muscles, muscle myalgia, neck pain. Infections: infrequently — candidiasis, herpes simplex, nasopharyngitis, pharyngitis, upper respiratory tract infections; unknown — Clostridial infection. Reproductive system: infrequently polymenorrhea. Other: often — fever. infrequently — rash, sunburn; unknown angioedema, allergic dermatitis, exfoliative dermatitis, eczema, erythema, pruritus, purpura, urticaria, erythematous rash, erythema of the palms, itching of the genitals.On the part of the musculoskeletal system: infrequently — back pain, spasm, muscles, muscle myalgia, neck pain. Infections: infrequently — candidiasis, herpes simplex, nasopharyngitis, pharyngitis, upper respiratory tract infections; unknown — Clostridial infection. Reproductive system: infrequently polymenorrhea. Other: often — fever. muscle weakness, myalgia, neck pain. Infections: infrequently — candidiasis, herpes simplex, nasopharyngitis, pharyngitis, upper respiratory tract infections; unknown — Clostridial infection. Reproductive system: infrequently polymenorrhea. Other: often — fever. muscle weakness, myalgia, neck pain. Infections: infrequently — candidiasis, herpes simplex,