Megafen 20 tablets

Tradename

Megafen

Megafen

Compound:

Each tablet contains:

Ibuprofen 200 mg

Paracetamol 325 mg

Properties

Combined drug, the action of which is due to its constituent components.

Ibuprofen — NSAIDs, has analgesic, anti-inflammatory, antipyretic effect. By inhibiting COX-1 and COX-2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (mediators of pain, inflammation and hyperthermia), both in the focus of inflammation and in healthy tissues, and suppresses the exudative and proliferative phases of inflammation.

Paracetamol — indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and the gastrointestinal mucosa. It has an analgesic and antipyretic effect. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX-1 and COX-2, which explains the low anti-inflammatory effect.

Indications

— symptomatic therapy of infectious and inflammatory diseases (colds, flu), accompanied by fever, chills, headache, muscle and joint pain, sore throat;

— myalgia;

-neuralgia;

Dosage and administration

Adults and children over 12 years of age:

1 tablet 3 times a day with meals.

Children 6-12 years old: 0.5 tablets 3 times a day with meals.

Contraindications

— peptic ulcer of the stomach and duodenum in the acute phase;

— gastrointestinal bleeding;

— severe renal failure (CC less than 30 ml / min);

Side effects

From the digestive system: NSAID-gastropathy — nausea, vomiting, heartburn, anorexia, epigastric discomfort or pain, diarrhea, flatulence;

From the nervous system and sensory organs: headache, dizziness, insomnia;

From the side of the cardiovascular system: heart failure, increased blood pressure, tachycardia.