Downoprazol 40/1680 mg 7 sachets

Tradename

Downoprazol

Compound:

Each sachet contains:

Omeprazole 40 mg

Sodium bicarbonate 1680 mg

Auxiliary components:

Aspartame sodium carboxymethyl cellulose, orange flavor, menthol flavor, sucrose.

Properties

Omeprazole inhibits the enzyme H + — K + -ATPase (“proton pump”) in the parietal cells of the stomach and thereby blocks the final stage of hydrochloric acid synthesis. This leads to a decrease in the level of basal and stimulated secretion, regardless of the nature of the stimulus. After a single dose of the drug inside, the effect of omeprazole occurs within the first hour and lasts for 24 hours, the maximum effect is achieved after 2 hours. In patients with duodenal ulcer, taking 20 mg of omeprazole maintains intragastric pH = 3 for 17 hours. drug secretory activity is fully restored after 3-5 days.

Indications

peptic ulcer of the stomach and duodenum;

reflux esophagitis;

erosive and ulcerative lesions of the stomach and duodenum associated with the use of NSAIDs;

Dosage and administration

Take in the morning 1 hour before meals. Pour the contents of the sachet into a glass with 20 ml of water, stir and drink. Do not use liquid other than water!

Doses for people over 18:

Peptic ulcer of the stomach in the acute phase and erosive and ulcerative esophagitis: 20-40 mg per day for 4-8 weeks.

Contraindications

hypersensitivity to the drug;

childhood;

pregnancy;

Side effects

In rare cases, the following usually reversible side effects may occur.

On the part of the digestive system: diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disturbances, stomatitis, transient increase in plasma levels of liver enzymes; in patients with previous severe liver disease — hepatitis (including with jaundice), impaired liver function.

From the nervous system: headache, dizziness, agitation, drowsiness, insomnia, paresthesia, depression, hallucinations; in patients with severe concomitant somatic diseases, in patients with previous severe liver disease — encephalopathy.