Megamox 1 gr 14 tablets

Trade name:

Megamox

Megamox

Properties

Combined preparation of amoxicillin and clavulanic acid, a beta-lactamase inhibitor. It acts bactericidal, inhibits the synthesis of the bacterial wall.

Active against aerobic gram-positive bacteria (including beta-lactamase producing strains).

Clavulanic acid inhibits II, III, IV and V types of beta-lactamases, is not active against type I beta-lactamases produced by Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high affinity for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases.

Indications

Treatment of infectious and inflammatory diseases caused by susceptible pathogens: infections of the lower respiratory tract (bronchitis, pneumonia, pleural empyema, lung abscess); infections of ENT organs (sinusitis, tonsillitis, otitis media); infections of the genitourinary system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingo-oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvic peritonitis, soft chancre, gonorrhea); infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, abscess, phlegmon, wound infection); osteomyelitis; postoperative infections.

Dosage and administration

Children under 12 years old: 20-40 mg / kg / day in 2-3 doses.

Adults and children over 12 years of age or weighing 40 kg or more: 250-500 mg 2-3 times / day or 875 mg 2 times / day.

The maximum daily dose of amoxicillin for adults and children over 12 years old is 6 g, for children under 12 years old — 45 mg / kg of body weight.

Contraindications

Hypersensitivity to amoxicillin and other penicillins, clavulanic acid, other beta-lactam antibiotics (cephalosporins, carbapenems, monobactams);

— cholestatic jaundice and / or other abnormal liver function caused by the use of amoxicillin / clavulanic acid in history; — severe renal dysfunction (CC <30 ml / min) (for a dosage form intended for use in children from 3 months to 12 years old);

— children’s age up to 3 months. With caution:

Side effects

From the digestive system: nausea, vomiting, diarrhea, gastritis, stomatitis, glossitis, increased activity of hepatic transaminases, in isolated cases — cholestatic jaundice, hepatitis.

On the part of the hematopoietic organs: a reversible increase in prothrombin time and bleeding time, thrombocytopenia, thrombocytosis.

From the nervous system: dizziness, headache, hyperactivity, anxiety, behavioral changes, convulsions.