Amikacin 500mg/2 ml vial

Tradename

Amikacin vial (Amikacin vial)

Compound:

Each 2 ml vial contains:

Amikacin (as sulfate) 500 mg

Properties

Semi-synthetic broad-spectrum antibiotic from the group of aminoglycosides, acts bactericidal. By binding to the 30S subunit of ribosomes, it prevents the formation of a complex of transport and messenger RNA, blocks protein synthesis, and also destroys the cytoplasmic membranes of bacteria.

Highly active against aerobic gram-negative microorganisms: Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Salmonella spp., Shigella spp.; some Gram-positive microorganisms: Staphylococcus spp. (including resistant to penicillin, some cephalosporins).

Moderately active against Streptococcus spp.

Indications

Infectious and inflammatory diseases caused by gram-negative microorganisms (resistant to gentamicin, sisomycin and kanamycin) or associations of gram-positive and gram-negative microorganisms:

— respiratory tract infections (bronchitis, pneumonia, pleural empyema, lung abscess);

-sepsis;

Dosage and administration

The drug is administered intramuscularly, intravenously (by jet, for 2 minutes or by drip) for adults and children over 6 years old — 5 mg / kg every 8 hours or 7.5 mg / kg every 12 hours. With bacterial infections of the urinary tract ( uncomplicated) — 250 mg every 12 hours; after a hemodialysis session, an additional dose of 3-5 mg / kg may be prescribed.

The maximum dose for adults is 15 mg / kg / day, but not more than 1.5 g / day for 10 days. The duration of treatment with a / in the introduction — 3-7 days, with a / m — 7-10 days.

Indications

— neuritis of the auditory nerve;

— severe chronic renal failure with azotemia and uremia;

-pregnancy;

Side effects

From the digestive system: nausea, vomiting, impaired liver function.

From the hemopoietic system: anemia, leukopenia, granulocytopenia, thrombocytopenia.

From the side of the central nervous system and peripheral nervous system: headache, drowsiness, neurotoxic effect.