Glucovance 500/2.5 mg 30 tablets

Trade name:

Glucovans

Glucovance

Properties

The combined oral hypoglycemic drug contains a second generation sulfonylurea derivative and a biguanide. It has pancreatic and extrapancreatic effects.

Glibenclamide is a second generation sulfonylurea derivative. Stimulates insulin secretion by lowering the threshold of glucose irritation of pancreatic β-cells, increases insulin sensitivity and the degree of its binding to target cells, increases insulin release, enhances the effect of insulin on glucose uptake by muscles and liver, and inhibits lipolysis in adipose tissue. Acts in stage II of insulin secretion.

Metformin belongs to the group of biguanides. Stimulates the peripheral sensitivity of tissues to the action of insulin (increases the binding of insulin to receptors, enhances the effects of insulin at the post-receptor level), reduces the absorption of glucose in the intestine, suppresses gluconeogenesis and has a beneficial effect on lipid metabolism, helps to reduce excess body weight in patients with diabetes mellitus, and also has a fibrinolytic effect due to the suppression of a tissue-type plasminogen activator inhibitor.

Indications

Type 2 diabetes mellitus with the ineffectiveness of diet therapy and previous therapy with sulfonylurea derivatives or biguanides, as well as other oral hypoglycemic agents.

Dosage and administration

The drug is taken orally during meals.

The dosage regimen and duration of treatment are set by the attending physician, depending on the state of carbohydrate metabolism and the concentration of glucose in the blood.

The initial dose is, as a rule, 1-3 tablets / day, with further gradual selection of an effective dose until a stable normalization of blood glucose concentration is achieved.

Contraindications

— type 1 diabetes mellitus;

— gestational diabetes mellitus;

— diabetic ketoacidosis, diabetic precoma, diabetic coma;

Side effects

From the digestive system: rarely — nausea, vomiting, loss of appetite, abdominal pain, diarrhea, metallic taste in the mouth;

From the hemopoietic system: rarely — leukopenia, thrombocytopenia, erythrocytopenia;

From the side of the central nervous system: infrequently — headache.