Blockadipine 20 mg

Trade Name:

Blockadipine

Composition

Each tablet contains:

Lercanidipine hydrochloride 20 mg

Inactive ingredients:

Lactose monohydrate, microcrystalline cellulose, purified water, Avicel, magnesium stearate.

Properties

Selective blocker of slow calcium channels with a predominant effect on blood vessels, a derivative of dihydropyridine. Inhibits the transmembrane current of calcium ions into vascular smooth muscle cells. The mechanism of the antihypertensive action of lercanidipine is due to a direct relaxing effect on vascular smooth muscle cells, resulting in a decrease in peripheral vascular resistance.

Despite the relatively short T1 / 2 from blood plasma, lercanidipine has a prolonged antihypertensive effect due to the high membrane distribution coefficient. Due to the high vascular selectivity, it does not have a negative inotropic effect. Acute arterial hypotension with reflex tachycardia rarely occurs due to the gradual development of vasodilation when taking lercanidipine.

Lercanidipine is a racemic mixture of (+)R- and (-)S-enantiomers. The antihypertensive effect of lercanidipine is primarily due to the S-enantiomer.

Indications

Essential hypertension I-II severity.

Dosage and administration

The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

Taken orally, at least 15 minutes before meals, preferably in the morning.

On average, administer 10 mg 1 time / day.Depending on the individual tolerability of the drug by the patient, the dose may be increased to 20 mg.

Contraindications

untreated heart failure;

unstable angina;

obstruction of vessels emanating from the left ventricle of the heart;

Side effects

From the nervous system: infrequently — headache, dizziness; rarely — drowsiness.

From the side of the cardiovascular system: infrequently — palpitations, tachycardia, flushing of blood to the skin of the face; rarely — angina pectoris, chest pain; very rarely — fainting, in patients with angina pectoris, an increase in the frequency, duration and severity of attacks is possible.

From the digestive system: rarely — nausea, dyspepsia, diarrhea, epigastric pain, vomiting.