Natrixam 1,5 mg/10 mg

Trade Name:

Natrixam

Composition

Indapamide 1,5 mg

Amlodipine 10 mg

Inactive ingredients:

Lactose monohydrate

Properties

Amlodipine is a calcium influx inhibitor, a dihydropyridine derivative (slow calcium channel blocker, or calcium ion antagonist), which inhibits the transmembrane influx of calcium ions into cardiomyocytes and smooth muscle cells of the vascular wall. The mechanism of the antihypertensive action of amlodipine is due to a direct relaxing effect on vascular smooth muscle.

Indapamide is a sulfonamide derivative with an indole ring, belonging to the pharmacological group of thiazide-like diuretics. Acts by reducing sodium reabsorption in the cortical segment of the nephron loop. Indapamide increases urinary sodium and chloride excretion and, to a lesser extent, potassium and magnesium excretion, thereby increasing diuresis and exerting an antihypertensive effect.

Indications

Dosage and administration

For oral use. 1 tablet once a day, preferably in the morning before meals. The tablet is swallowed whole, without chewing, with water. The maximum daily dose is 1 tablet (1.5 mg / 10 mg). The use of a fixed combination is not intended to initiate therapy. If it is necessary to change the dose, individual titration of each of the components of the combination should be carried out.

Special groups of patients.

Patients with impaired renal function.

Side effects

The most commonly reported adverse reactions reported with indapamide and amlodipine alone were hypokalemia, drowsiness, dizziness, headache, blurred vision, diplopia, palpitations, flushing, dyspnea, abdominal pain, nausea, dyspepsia, change in defecation rhythm, diarrhea , constipation, maculopapular rash, ankle edema, muscle cramps, edema, fatigue and asthenia.

Contraindications

Hypersensitivity to active substances, other sulfonamides, dihydropyridine derivatives or any excipients; severe renal failure (creatinine clearance <30 ml/min); hepatic encephalopathy or severe liver dysfunction; hypokalemia; period of breastfeeding; severe hypotension; shock (including cardiogenic); obstruction of the exit from the left ventricle (for example, severe aortic stenosis). Heart failure with unstable hemodynamics after acute myocardial infarction.

Warnings and precautions:

You should tell your doctor if you have experienced or are experiencing any of the following conditions:

Storage

Store at a temperature not exceeding 30°C.

Package:

The carton box holds 4 strips of 7 tablets and inner leaflet